List of figures and tables

Tables

Table 1: Summary of Phase 2 statistical analysis results of gene expression in pairwise comparison sets. 12

Table 2: Distribution of study genes throughout key cells and cellular components in asthma. 14

Table 3: Supplementary files list, describing source, type, content and location. 26

Figures

Figure 1: Spreadsheet of initial gene selection analysis of original dataset. 11

Figure 2: Comparison between DGE ratios of STAT2 and OAS genes, relative to control sample δ. 13

Figure 3. Pathway WP4880: IFN-I inducing JAK-STAT cascade, in ‘Host-pathogen interaction of human coronaviruses’. (WikiPathways, 2021) 14

Figure 4: Detail of JAK-STAT cascade in WP4880, showing STAT1, STAT2, OAS1, OAS2 & OAS3. (WikiPathways, 2021) 15

Figure 5: Generalized pathway diagram demonstrating the potential benefits of avoiding the default OAS-RNaseL pathway. 20