Table of Contents

1. Abstract

2. List of Abbreviations, Acronyms, Terms

3. Table of Contents

4. List of figures and tables

5. Introduction

   1. Asthma background

   2. Current research state

   3. Purpose for this study

   4. Intent & scope

6. Methods & materials

   1. Preliminary research

   2. Data sourcing

   3. Original experiment conditions

   4. Phase 1 – Data processing & gene selection

   5. Phase 2 – Data analysis

      1. Statistical analysis

      2. Second-order comparison

   6. Phase 3 – Literature research

7. Results

   1. Phase 1 – Gene selection

   2. Phase 2 – Statistical analysis

      1. Sets A & D – Wilcoxon Matched Pairs test

      2. Sets B & C – Mann–Whitney U-test

      3. Combining results

   3. Phase 3 – Literature research

      1. Key findings

      2. STAT genes

         1. STAT2

      3. OAS genes

         1. Macrophages

         2. OAS-RNase pathway

         3. RNaseL independence

8. Discussion

   1. Phase 2 – Statistical analysis

   2. Phase 3 – Literature research

   3. Experimental design & limitations

   4. Conclusions

9. References

10. Appendices

    1. Appendix 1 – Data files

    2. Appendix 2 – Orthography

    3. Appendix 3 – Text-based tables

    4. Appendix 4 – Software list

11. Glossary