# Appendix 1 – Data files

These files are available in the Supplementary Materials folder, inside the main zip file submission.

Table 3: Supplementary files list, describing source, type, content and location.

<table data-full-width="true"><thead><tr><th width="195">Source</th><th width="175">Data type</th><th>Description</th><th>Location (filename → sheet)</th></tr></thead><tbody><tr><td>Original experiment</td><td>Raw</td><td>Gene expression data.</td><td>E-GEOD-61141-raw-counts.tsv</td></tr><tr><td>Original experiment</td><td>Statistical analysis</td><td>Differential genetic expression data, represented as foldchange with significance <em>p</em>-values.</td><td>E-GEOD-61141-analytics.tsv</td></tr><tr><td>Original experiment</td><td>Experiment design</td><td>Tabulated 2D description of the original experiment setup</td><td>E-GEOD-61141-experiment-design.tsv</td></tr><tr><td>This research</td><td>Selected genes</td><td>Expression data of target genes, sample sets α,β,γ,δ.</td><td>E-GEOD-61141-raw-counts_graphs.xlsx → “target genes”</td></tr><tr><td>This research</td><td>Comparison pairs<br>– first order</td><td>Differential genetic expression data, comparison Sets A,B,C,D.</td><td>E-GEOD-61141-raw-counts_graphs.xlsx → [gene name]</td></tr><tr><td>This research</td><td>Statistical analysis</td><td>Stat analysis of DGE of Sets A,B,C,D.</td><td>E-GEOD-61141-raw-counts_graphs.xlsx → [gene name]</td></tr><tr><td>This research</td><td>Comparison sets<br>– second order</td><td>Comparison of foldchanges of each individual gene across all sets<br>(e.g. STAT2 in Set C vs Set D vs Set A vs Set B);<br>Comparison of foldchanges of each gene within each set<br>(e.g. STAT2 vs OAS1 vs OAS2 vs OAS3 in Set B).</td><td>E-GEOD-61141-raw-counts_graphs.xlsx → “Comparison”</td></tr><tr><td>This research</td><td>Image</td><td>Fig 1a: Gene expression query sorted by foldchange in Excel.</td><td>Fig-1a_Results_Phase1_gene_selection<br>_excel_sort_foldchange.png</td></tr><tr><td>This research</td><td>Image</td><td>Fig 1b: Gene expression query sorted by <em>p</em>-value in Excel.</td><td>Fig-1b_Results_Phase1_gene<br>_selection_excel_sort_p-val.png</td></tr><tr><td>This research</td><td>Image</td><td>Fig. 2: Bar chart of DGE foldchange comparison.</td><td>Fig-2_Results_Phase2_Chart_DGE<br>_ratios_annotated.png</td></tr><tr><td>This research</td><td>Image</td><td>Fig. 5: Flowchart of simplified OAS-RNaseL pathway to apoptosis with indication of non-RNaseL antiviral pathway.</td><td>Fig-5_Discussion_Phase3_Flowchart<br>_of_OAS_activation_chains.png</td></tr></tbody></table>
